SCHEMBL8121978

SCHEMBL8121978

Oc1ncnc2c1c(Nc1cccc(Cl)c1)nn2Cc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRC P12931 6/20 0.53
EGFR P00533 5/20 0.47
CDK1 P06493 3/20 0.47
ABL1 P00519 2/20 0.47
PRKCA P17252 2/20 0.47
PRMT5 O14744 1/20 0.47
ALDH1A1 P00352 2/20 0.47
MAPT P10636 2/20 0.47
KDM4E B2RXH2 2/20 0.47
MEN1 O00255 1/20 0.47
LMNA P02545 1/20 0.47
GAA P10253 1/20 0.47
HPGD P15428 1/20 0.47
TSHR P16473 1/20 0.47
HTT P42858 1/20 0.47
KMT2A Q03164 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
HSD17B10 Q99714 1/20 0.47
MKNK1 Q9BUB5 1/20 0.45
FADS1 O60427 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8125505 0.90 SRC (0.55) SRCEGFRCDK1ABL1PRKCA
SCHEMBL8129590 0.90 SRC (0.58) SRCEGFRCDK1ABL1PRKCA
SCHEMBL8123771 0.90 ALDH1A1 (0.50) ABL1PRMT5ALDH1A1MAPTKDM4E
SCHEMBL8123792 0.89 SRC (0.57) SRCEGFRCDK1ABL1PRKCA
SCHEMBL13064030 0.84 MAPT (0.62) SRCEGFRCDK1ABL1PRKCA
SCHEMBL8121867 0.84 MAPT (0.62) SRCEGFRCDK1ABL1PRKCA
SCHEMBL8122075 0.84 EGFR (0.53) SRCEGFRCDK1ABL1PRKCA
SCHEMBL13064037 0.84 EGFR (0.53) SRCEGFRCDK1ABL1PRKCA
SCHEMBL6190167 0.83 ALDH1A1 (0.44) ABL1PRMT5ALDH1A1MAPTKDM4E
SCHEMBL6185651 0.83 SRC (0.53) SRCEGFRCDK1ABL1PRKCA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0819129-B1 PYRAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF NOVARTIS AG (CH) 2000-08-02 EP disclosed
US-5981533-A INHIBIT THE TYROSINE KINASE ACTIVITY OF THE RECEPTOR FOR EPIDERMAL GROWTH FACTOR AND CAN BE USED IN THE CASE OF EPIDERMAL HYPERPROLIFERATION (PSORIASIS) AND AS ANTI-TUMOR AGENTS NOVARTIS AG (CH) 1999-11-09 US disclosed
WO-1998014449-A1 FUSED PYRAZOLE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION NOVARTIS AG (CH) 1998-04-09 WO disclosed
EP-0819129-A1 PYRAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF Novartis AG (CH) 1998-01-21 EP disclosed
WO-1996031510-A1 PYRAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF NOVARTIS AG (CH) 1996-10-10 WO disclosed