Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8122189 | 0.86 | MEN1 (0.62) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL8120084 | 0.85 | MEN1 (0.56) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL8124815 | 0.82 | APP (0.47) | HTTSMN1; SMN2ALOX5KDM4ETP53 | |
| SCHEMBL8125037 | 0.82 | HTT (0.55) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL8102028 | 0.80 | HTT (0.70) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL8108601 | 0.79 | HTT (0.68) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL20382958 | 0.79 | HTT (0.71) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL30669320 | 0.79 | HTT (0.75) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL8115513 | 0.78 | MEN1 (0.58) | HTTSMN1; SMN2MEN1ALDH1A1HPGD | |
| SCHEMBL9515266 | 0.78 | HTT (0.67) | HTTSMN1; SMN2MEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519353-B1 | Indolizin derivatives, process for their preparation and pharmaceutical composition containing them | FUJISAWA PHARMACEUTICAL CO (JP) | 2000-08-16 | — | — | EP | claimed |
| EP-1027335-A1 | ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS | Cerebrus Pharmaceuticals Limited (GB) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999023075-A1 | ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS | CEREBRUS PHARMACEUTICALS LIMITED (GB) | 1999-05-14 | — | — | WO | disclosed |