Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 7/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | KDM6A | O15550 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM5C | P41229 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.42 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8126192 | 0.92 | KDM4E (0.49) | APPHRH3KDM4ETP53CYP2D6 | |
| SCHEMBL8122576 | 0.82 | HTT (0.57) | KDM4ETP53CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL8121689 | 0.80 | APP (0.47) | APPHRH3KDM4ETP53CYP2D6 | |
| SCHEMBL10359200 | 0.77 | APP (0.61) | APPHRH3KDM4ETP53CYP2D6 | |
| SCHEMBL9513592 | 0.77 | APP (0.61) | APPHRH3KDM4ETP53CYP2D6 | |
| SCHEMBL9386911 | 0.76 | APP (0.54) | APPHRH3KDM4ETP53CYP2D6 | |
| SCHEMBL8127562 | 0.76 | APP (0.46) | APPHRH3KDM4ETP53CYP2D6 | |
| SCHEMBL8124088 | 0.75 | APP (0.43) | APPHRH3KDM4ETP53CYP2D6 | |
| SCHEMBL5136933 | 0.74 | APP (0.58) | APPHRH3KDM4ETP53CYP2D6 | |
| SCHEMBL7152347 | 0.74 | APP (0.58) | APPHRH3KDM4ETP53CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027335-A1 | ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS | Cerebrus Pharmaceuticals Limited (GB) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999023075-A1 | ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS | CEREBRUS PHARMACEUTICALS LIMITED (GB) | 1999-05-14 | — | — | WO | disclosed |