Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FADS1 | O60427 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 6/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | CCNC | P24863 | 1/20 | 0.53 |
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.50 |
| ▸ | ARNT | P27540 | 1/20 | 0.50 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8122583 | 0.86 | EGFR (0.68) | EGFRUSP2MAPTKMT2ACCNC | |
| SCHEMBL7620689 | 0.86 | EGFR (0.58) | FADS1EGFRCA9USP2MAPT | |
| SCHEMBL19633804 | 0.83 | FADS1 (0.56) | FADS1EGFRCA9MAPTKMT2A | |
| SCHEMBL7619895 | 0.83 | EGFR (0.58) | FADS1EGFRCA9USP2MAPT | |
| SCHEMBL9069952 | 0.83 | GAK (0.63) | EGFRUSP2MAPTKMT2ACCNC | |
| SCHEMBL7624054 | 0.82 | MAPT (0.58) | EGFRUSP2MAPTKMT2ACCNC | |
| SCHEMBL8871973 | 0.81 | EGFR (0.83) | FADS1EGFRMAPTKMT2AKDM4E | |
| SCHEMBL6071727 | 0.81 | PTK6 (0.50) | FADS1EGFRCA9PTK6ARNT | |
| SCHEMBL7617075 | 0.79 | MAPT (0.63) | EGFRUSP2MAPTKMT2ACCNC | |
| SCHEMBL15614056 | 0.79 | FADS1 (0.71) | FADS1EGFRCA9PTK6MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973746-A1 | SUBSTITUTED 3-CYANO QUINOLINES | American Cyanamid Company (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998043960-A1 | SUBSTITUTED 3-CYANO QUINOLINES | AMERICAN CYANAMID COMPANY (US) | 1998-10-08 | — | — | WO | disclosed |