Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 3/20 | 0.42 |
| ▸ | F2 | P00734 | 6/20 | 0.42 |
| ▸ | C1S | P09871 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975715 | 0.92 | F10 (0.42) | F10F2C1SHTR1ADRD4 | |
| SCHEMBL6979694 | 0.91 | F10 (0.42) | F10F2C1SHTR1ADRD4 | |
| SCHEMBL6985250 | 0.91 | F10 (0.42) | F10F2C1SHTR1ADRD4 | |
| SCHEMBL6983152 | 0.90 | F10 (0.43) | F10F2ALDH1A1MAPT | |
| SCHEMBL6983673 | 0.90 | HTR1A (0.47) | F10F2HTR1ADRD4ALDH1A1 | |
| SCHEMBL6980046 | 0.90 | CTDSP1 (0.41) | F10F2C1SALDH1A1MAPT | |
| SCHEMBL6984824 | 0.89 | F10 (0.50) | F10F2C1SHTR1ADRD4 | |
| SCHEMBL6979831 | 0.88 | F10 (0.44) | F10F2C1SHTR1ADRD4 | |
| SCHEMBL6982494 | 0.88 | C1S (0.41) | F10F2C1SALDH1A1MAPT | |
| SCHEMBL6983358 | 0.88 | POLB (0.43) | F10F2C1SALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012166-A1 | 1-AMINO-7-ISOQUINOLINE DERIVATIVES AS SERINE PROTEASE INHIBITORS | Protherics Molecular Design Limited (GB) | 2000-06-28 | — | — | EP | disclosed |
| WO-1999011657-A1 | 1-AMINO-7-ISOQUINOLINE DERIVATIVES AS SERINE PROTEASE INHIBITORS | PROTEUS MOLECULAR DESIGN LTD. (GB) | 1999-03-11 | — | — | WO | disclosed |