Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.48 |
| ▸ | LTB4R | Q15722 | 12/20 | 0.46 |
| ▸ | PTGIR | P43119 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9771007 | 0.83 | MEN1 (0.51) | LTB4RPTGIRKMT2A | |
| SCHEMBL9771033 | 0.83 | MEN1 (0.51) | LTB4RPTGIRKMT2A | |
| SCHEMBL9210200 | 0.81 | PTGIR (0.68) | TBXAS1LTB4RPTGIRFAAH | |
| SCHEMBL5371862 | 0.78 | FAAH (0.69) | RXRANR4A2FAAH | |
| SCHEMBL8104458 | 0.77 | PTGIR (0.67) | PTGIRRXRANR4A2FAAH | |
| SCHEMBL8104410 | 0.77 | PTGIR (0.67) | PTGIRRXRANR4A2FAAH | |
| Biphenyl SCHEMBL9325687 | 0.75 | ACE2 (0.61) | LTB4R | |
| SCHEMBL8118256 | 0.75 | PTGIR (0.48) | PTGIR | |
| SCHEMBL8103988 | 0.74 | FAAH (0.61) | TBXAS1LTB4RPTGIRFAAHKMT2A | |
| SCHEMBL8112625 | 0.72 | FAAH (0.64) | PTGIRFAAHKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626969-B1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2000-05-24 | — | — | EP | disclosed |
| US-5663053-A | COENZYME A TRANSACYLASE FOR SCREENING | SMITHKLINE BEECHAM CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| US-5648373-A | CoA-IT and PAF inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-15 | — | — | US | disclosed |
| EP-0626969-A4 | CoA-IT AND PAF INHIBITORS. | SMITHKLINE BEECHAM CORP (US) | 1995-04-19 | — | — | EP | disclosed |
| EP-0626969-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-12-07 | — | — | EP | disclosed |
| WO-1993016674-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-02 | — | — | WO | disclosed |