Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 6/20 | 1.00 |
| ▸ | JAK1 | P23458 | 4/20 | 1.00 |
| ▸ | JAK2 | O60674 | 4/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 1.00 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | MAPK7 | Q13164 | 3/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3515504 | 0.89 | TYK2 (1.00) | TYK2JAK1JAK2HTTNOD2 | |
| SCHEMBL3512704 | 0.89 | TYK2 (0.79) | TYK2JAK1JAK2HTTNOD2 | |
| SCHEMBL3515796 | 0.86 | TYK2 (0.75) | TYK2JAK1JAK2HTTNOD2 | |
| SCHEMBL30739749 | 0.83 | JAK2 (0.71) | TYK2JAK1JAK2HTTNOD2 | |
| SCHEMBL30739821 | 0.81 | JAK2 (0.69) | TYK2JAK1JAK2HTTNOD2 | |
| SCHEMBL8120027 | 0.81 | HTT (0.77) | TYK2JAK1JAK2HTTNOD2 | |
| SCHEMBL3514109 | 0.81 | TYK2 (0.69) | TYK2JAK1JAK2HTTNOD2 | |
| SCHEMBL1057314 | 0.79 | JAK2 (0.65) | TYK2JAK1JAK2HTTNOD2 | |
| SCHEMBL678422 | 0.79 | JAK2 (0.65) | TYK2JAK1JAK2HTTNOD2 | |
| SCHEMBL7927691 | 0.79 | JAK2 (0.65) | TYK2JAK1JAK2HTTNOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848713-B1 | PYRIDINIMINYL-1,2-BENZISOXAZOLES AND- BENZISOTHIAZOLES AS ANTIPSYCHOTIC AGENTS | AVENTIS PHARMA INC (US) | 2000-10-25 | — | — | EP | disclosed |
| EP-0848713-A1 | PYRIDINIMINYL-1,2-BENZISOXAZOLES AND- BENZISOTHIAZOLES AS ANTIPSYCHOTIC AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1998-06-24 | — | — | EP | disclosed |
| US-5728717-A | COGNITION ACTIVATORS, ANTIDEPRESSANTS | HOECHST MARION ROUSSEL INC. (US) | 1998-03-17 | — | — | US | disclosed |
| US-5668154-A | TREATMENT OF MEMORY DYSFUNCTION, ALZHEIMER*S DISEASE, ANTIDEPRESSANTS | HOECHST MARION ROUSSEL INC. (US) | 1997-09-16 | — | — | US | disclosed |
| WO-1996039405-A1 | PYRIDINIMINYL-1,2-BENZISOXAZOLES AND- BENZISOTHIAZOLES AS ANTIPSYCHOTIC AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1996-12-12 | — | — | WO | disclosed |