Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.57 |
| ▸ | RAB9A | P51151 | 10/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 5/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8125604 | 0.85 | CSNK2A2 (0.56) | NPC1RAB9AKDM4EKMT2AMEN1 | |
| SCHEMBL2421423 | 0.82 | KDM4E (0.75) | NPC1RAB9AKDM4EKMT2AMEN1 | |
| SCHEMBL8143035 | 0.80 | SMN1; SMN2 (0.71) | NPC1RAB9AKDM4EKMT2AMEN1 | |
| SCHEMBL2423069 | 0.80 | KDM4E (0.74) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL8151030 | 0.80 | NPC1 (0.53) | NPC1RAB9AKDM4EKMT2AMEN1 | |
| SCHEMBL6215399 | 0.79 | NPC1 (0.60) | NPC1RAB9AKDM4EKMT2AMEN1 | |
| SCHEMBL3828303 | 0.78 | NPC1 (0.71) | NPC1RAB9AKDM4EKMT2AMEN1 | |
| SCHEMBL2420013 | 0.77 | CSNK2A2 (0.78) | NPC1RAB9AKDM4EKMT2AMEN1 | |
| SCHEMBL18788945 | 0.75 | NPC1 (0.67) | NPC1RAB9AKDM4EKMT2AMEN1 | |
| SCHEMBL9893004 | 0.75 | CSNK2A2 (0.74) | NPC1RAB9AKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054876-A1 | 1,3,4-THIADIAZOLES DERIVATIVES AS KYN-OH INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999028309-A1 | 1,3,4-THIADIAZOLES DERIVATIVES AS KYN-OH INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-10 | — | — | WO | disclosed |