Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.74 |
| ▸ | RAB9A | P51151 | 4/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.71 |
| ▸ | HPGD | P15428 | 5/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | USP2 | O75604 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | CSNK2A2 | P19784 | 6/20 | 0.63 |
| ▸ | CSNK2A1 | P68400 | 6/20 | 0.63 |
| ▸ | GLS | O94925 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8143035 | 0.86 | SMN1; SMN2 (0.71) | KDM4ERAB9AHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL255828 | 0.85 | ALDH1A1 (0.64) | KDM4ERAB9AHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL2421423 | 0.85 | KDM4E (0.75) | KDM4ERAB9AHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL20887242 | 0.82 | KDM4E (0.79) | KDM4ERAB9AHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL8125604 | 0.82 | CSNK2A2 (0.56) | KDM4ERAB9AHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL8151030 | 0.82 | NPC1 (0.53) | KDM4ERAB9AHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL3828303 | 0.81 | NPC1 (0.71) | KDM4ERAB9ASMN1; SMN2ALDH1A1USP2 | |
| SCHEMBL14962997 | 0.81 | KDM4E (0.76) | KDM4ERAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL15515850 | 0.81 | KDM4E (0.60) | KDM4ERAB9AHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL8124696 | 0.80 | NPC1 (0.57) | KDM4ERAB9AHSD17B10SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202859-B2 | Heterocyclic sulfonamides | CYTOKINETICS, INC. (US) | 2012-06-19 | — | — | US | disclosed |
| EP-1605752-B1 | Sulfonamides for the treatment of congestive heart failure, their compositions and uses. | CYTOKINETICS INC (US) | 2011-09-14 | — | — | EP | disclosed |