Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.56 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.56 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.56 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.56 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.56 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.56 |
| ▸ | ICMT | O60725 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 12/20 | 0.52 |
| ▸ | CNR1 | P21554 | 8/20 | 0.52 |
| ▸ | CDC25A | P30304 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8138365 | 0.82 | CDC25A (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8121101 | 0.78 | CNR2 (0.62) | ICMTCNR2CNR1CDC25A | |
| SCHEMBL28034310 | 0.77 | CNR2 (0.60) | ICMTCNR2CNR1CDC25A | |
| SCHEMBL28034290 | 0.77 | CNR2 (0.60) | ICMTCNR2CNR1CDC25A | |
| SCHEMBL5462804 | 0.77 | CDC25A (0.70) | ICMTCNR2CNR1CDC25A | |
| SCHEMBL28034936 | 0.76 | CDC25A (0.58) | ICMTCNR2CNR1CDC25A | |
| SCHEMBL28034295 | 0.76 | CDC25A (0.58) | ICMTCNR2CNR1CDC25A | |
| SCHEMBL168724 | 0.75 | CDC25A (0.59) | ICMTCNR2CNR1CDC25A | |
| SCHEMBL8126918 | 0.75 | CDC25A (0.64) | ICMTCNR2CNR1CDC25A | |
| SCHEMBL25433436 | 0.74 | CNR2 (0.79) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734384-B1 | 3-SUBSTITUTED 1-ARYLINDOLE COMPOUNDS | LUNDBECK & CO AS H (DK) | 2000-08-09 | — | — | EP | disclosed |
| EP-0939077-A2 | 3-Substituted 1-arylindole compounds as 5-HT2 antagonists | H. LUNDBECK A/S (DK) | 1999-09-01 | — | — | EP | disclosed |
| US-5789404-A | CENTRAL NERVOUS SYSTEM DISORDERS AND ANTISEROTONIN AGENTS | H. LUNDBECK A/S (DK) | 1998-08-04 | — | — | US | disclosed |
| EP-0734384-A1 | 3-SUBSTITUTED 1-ARYLINDOLE COMPOUNDS | H. LUNDBECK A/S (DK) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995016684-A1 | 3-SUBSTITUTED 1-ARYLINDOLE COMPOUNDS | H. LUNDBECK A/S (DK) | 1995-06-22 | — | — | WO | disclosed |