SCHEMBL8125918

SCHEMBL8125918

COc1ccc2oc(Cc3cccc(Cl)c3)c(CCNC(C)=O)c2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 20/20 1.00
MTNR1B P49286 19/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7022296 0.92 MTNR1A (1.00) MTNR1AMTNR1B
SCHEMBL8124513 0.89 MTNR1A (1.00) MTNR1AMTNR1B
SCHEMBL8125927 0.89 MTNR1A (1.00) MTNR1AMTNR1B
SCHEMBL8133099 0.87 MTNR1A (1.00) MTNR1AMTNR1B
SCHEMBL8131063 0.87 MTNR1A (1.00) MTNR1AMTNR1B
SCHEMBL7027012 0.86 MTNR1A (0.87) MTNR1AMTNR1B
SCHEMBL8118762 0.86 MTNR1A (1.00) MTNR1AMTNR1B
SCHEMBL7019533 0.85 MTNR1A (0.87) MTNR1AMTNR1B
SCHEMBL7955743 0.85 MTNR1A (0.85) MTNR1AMTNR1B
SCHEMBL8132560 0.85 MTNR1A (1.00) MTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6147110-A MELATONINERGIC AGENTS; SLEEP, EATING, CENTRAL NERVOUS SYSTEM, AND CARDIOVASCULAR DISORDERS ADIR ET COMPAGNIE (FR) 2000-11-14 US disclosed
EP-0926145-A1 Napthalene compounds, method for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 1999-06-30 EP disclosed