Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 5/20 | 0.39 |
| ▸ | HTR2B | P41595 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8126092 | 1.00 | AKR1B1 (0.43) | AKR1B1HRH1HTR2BKCNH2ALDH1A1 | |
| SCHEMBL8135265 | 0.88 | AKR1B1 (0.45) | AKR1B1HRH1HTR2BKCNH2ALDH1A1 | |
| SCHEMBL4360929 | 0.88 | AKR1B1 (0.45) | AKR1B1HRH1HTR2BKCNH2ALDH1A1 | |
| SCHEMBL4360936 | 0.88 | AKR1B1 (0.45) | AKR1B1HRH1HTR2BKCNH2ALDH1A1 | |
| SCHEMBL1918498 | 0.82 | LMNA (0.35) | HRH1HTR2BKCNH2ALDH1A1LMNA | |
| SCHEMBL1918496 | 0.82 | LMNA (0.35) | HRH1HTR2BKCNH2ALDH1A1LMNA | |
| SCHEMBL11609289 | 0.81 | HTR2B (0.51) | HRH1HTR2BKCNH2ALDH1A1LMNA | |
| SCHEMBL14415807 | 0.81 | HTR2B (0.51) | HRH1HTR2BKCNH2ALDH1A1LMNA | |
| SCHEMBL1918425 | 0.79 | HTR2B (0.45) | AKR1B1HRH1HTR2BKCNH2ALDH1A1 | |
| SCHEMBL1917023 | 0.79 | HTR2B (0.42) | AKR1B1HRH1HTR2BKCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549352-B1 | Tricyclic compounds as angiotensin II antagonists | KYOWA HAKKO KOGYO KK (JP) | 2000-03-01 | — | — | EP | disclosed |
| US-5478840-A | Imidazo(4,5-b)pyridine derivatives used as antagonism to angiotensin ii receptors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5378701-A | Angiotensin II inhibitors; hypotensive agents; congestive heart and kidney failure; glaucoma | KYOWA HAKKO KOGYO (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0549352-A2 | Tricyclic compounds as angiotensin II antagonists | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-06-30 | — | — | EP | disclosed |