Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.34 |
| ▸ | CFB | P00751 | 11/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1346579 | 0.83 | JAK2 (0.35) | DAOROCK1BRD4 | |
| SCHEMBL1346674 | 0.82 | DAO (0.41) | DAOBRD4 | |
| SCHEMBL2172919 | 0.70 | DAO (0.38) | DAOROCK1BRD4 | |
| SCHEMBL27157561 | 0.67 | DAO (0.36) | DAOROCK1BRD4 | |
| SCHEMBL10110509 | 0.67 | NOS3 (0.35) | DAOBRD4 | |
| SCHEMBL8112120 | 0.67 | DAO (0.39) | DAOPARP14GRM1BRD4 | |
| SCHEMBL8150665 | 0.67 | DAO (0.39) | DAOPARP14GRM1BRD4 | |
| SCHEMBL9284095 | 0.66 | AURKA (0.34) | DAOBRD4 | |
| SCHEMBL17060505 | 0.66 | DAO (0.34) | DAOBRD4 | |
| SCHEMBL3174185 | 0.65 | SMN1; SMN2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045836-A1 | PYRIDONES AS SRC FAMILY SH2 DOMAIN INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999031066-A1 | PYRIDONES AS SRC FAMILY SH2 DOMAIN INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |