Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.49 |
| ▸ | GHSR | Q92847 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12765134 | 0.87 | HDAC8 (0.47) | HDAC8GHSRMEN1KMT2AFFAR1 | |
| SCHEMBL1634598 | 0.86 | HDAC8 (0.53) | HDAC8PTPN1 | |
| SCHEMBL7945553 | 0.86 | HDAC8 (0.53) | HDAC8PTPN1 | |
| SCHEMBL1636444 | 0.84 | PTPN1 (0.58) | HDAC8PTPN1 | |
| SCHEMBL7935988 | 0.84 | PTPN1 (0.58) | HDAC8PTPN1 | |
| SCHEMBL29798802 | 0.81 | HDAC8 (0.46) | HDAC8MEN1KMT2APTPN1 | |
| SCHEMBL2730295 | 0.81 | HDAC8 (0.46) | HDAC8MEN1KMT2APTPN1 | |
| SCHEMBL19329217 | 0.78 | HDAC8 (0.53) | HDAC8PTPN1 | |
| SCHEMBL19329216 | 0.78 | HDAC8 (0.53) | HDAC8PTPN1 | |
| SCHEMBL8107263 | 0.78 | ESR2 (0.64) | HDAC8GHSRSTS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829665-B2 | Macrocyclic inhibitors of hepatitis C virus replication | INTERMUNE, INC. (US) | 2010-11-09 | — | — | US | disclosed |
| WO-2008141227-A1 | NOVEL PEPTIDE INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2008-11-20 | — | — | WO | disclosed |