Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | GAA | P10253 | 7/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8124094 | 0.94 | GAA (0.35) | ALDH1A1GAAKMT2AMEN1TDP1 | |
| SCHEMBL8128215 | 0.84 | KDM4E (0.44) | GAAKMT2AMEN1TDP1KDM4E | |
| SCHEMBL8128029 | 0.82 | KDM4E (0.49) | ALDH1A1GAAKMT2AMEN1TDP1 | |
| SCHEMBL8115513 | 0.81 | MEN1 (0.58) | ALDH1A1GAAKMT2AMEN1KDM4E | |
| SCHEMBL8124088 | 0.78 | APP (0.43) | GAAKMT2AMEN1TDP1KDM4E | |
| SCHEMBL8121689 | 0.76 | APP (0.47) | ALDH1A1GAAKMT2AMEN1TDP1 | |
| SCHEMBL8120084 | 0.75 | MEN1 (0.56) | ALDH1A1GAAKMT2AMEN1KDM4E | |
| SCHEMBL8127562 | 0.75 | APP (0.46) | ALDH1A1GAAKMT2AMEN1TDP1 | |
| SCHEMBL8125037 | 0.74 | HTT (0.55) | ALDH1A1GAAKMT2AMEN1KDM4E | |
| SCHEMBL8122410 | 0.72 | KDM4E (0.41) | ALDH1A1GAAKMT2AMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027335-A1 | ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS | Cerebrus Pharmaceuticals Limited (GB) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999023075-A1 | ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS | CEREBRUS PHARMACEUTICALS LIMITED (GB) | 1999-05-14 | — | — | WO | disclosed |