Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KDM6A | O15550 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.44 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | MAOB | P27338 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8128215 | 0.94 | KDM4E (0.44) | KDM4ECYP2D6TP53HTTSMN1; SMN2 | |
| SCHEMBL8121689 | 0.92 | APP (0.47) | KDM4ECYP2D6TP53HTTSMN1; SMN2 | |
| SCHEMBL8127562 | 0.91 | APP (0.46) | KDM4ECYP2D6TP53HTTSMN1; SMN2 | |
| SCHEMBL8124088 | 0.87 | APP (0.43) | KDM4ECYP2D6TP53HTTSMN1; SMN2 | |
| SCHEMBL8122410 | 0.85 | KDM4E (0.41) | KDM4ECYP2D6TP53HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8136802 | 0.83 | GSR (0.53) | KDM4ECYP2D6TP53HTTSMN1; SMN2 | |
| SCHEMBL8128222 | 0.82 | ALDH1A1 (0.36) | KDM4ECYP2D6TP53HTTSMN1; SMN2 | |
| SCHEMBL8128163 | 0.82 | GAA (0.51) | KDM4ECYP2D6TP53HTTSMN1; SMN2 | |
| SCHEMBL8115513 | 0.81 | MEN1 (0.58) | KDM4ECYP2D6TP53HTTSMN1; SMN2 | |
| SCHEMBL8118150 | 0.81 | KDM4E (0.46) | KDM4ECYP2D6TP53HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027335-A1 | ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS | Cerebrus Pharmaceuticals Limited (GB) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999023075-A1 | ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS | CEREBRUS PHARMACEUTICALS LIMITED (GB) | 1999-05-14 | — | — | WO | disclosed |