Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 3/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GPR183 | P32249 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8128377 | 1.00 | SMN1; SMN2 (0.60) | SMN1; SMN2KDM4EDRD2HTR2AHTR2C | |
| SCHEMBL8429460 | 0.95 | KDM4E (0.60) | SMN1; SMN2KDM4EDRD2NPC1RAB9A | |
| SCHEMBL8429465 | 0.95 | KDM4E (0.60) | SMN1; SMN2KDM4EDRD2NPC1RAB9A | |
| SCHEMBL8429503 | 0.90 | KDM4E (0.64) | SMN1; SMN2KDM4EDRD2HTR2ASIGMAR1 | |
| SCHEMBL8429501 | 0.90 | KDM4E (0.64) | SMN1; SMN2KDM4EDRD2HTR2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL8428831 | 0.89 | KDM4E (0.66) | SMN1; SMN2KDM4EDRD2HTR2ANPC1 | |
| Hydrochloric Acid SCHEMBL8428835 | 0.89 | KDM4E (0.66) | SMN1; SMN2KDM4EDRD2HTR2ANPC1 | |
| SCHEMBL8430804 | 0.88 | KDM4E (0.53) | SMN1; SMN2KDM4EDRD2KMT2A | |
| SCHEMBL8430800 | 0.88 | KDM4E (0.53) | SMN1; SMN2KDM4EDRD2KMT2A | |
| SCHEMBL8427010 | 0.88 | KDM4E (0.62) | SMN1; SMN2KDM4EDRD2SIGMAR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775138-B1 | TETRAHYDROPYRIDINYLMETHYL DERIVATIVES OF PYRROLO 2,3-b]PYRIDINE | MERCK SHARP & DOHME (GB) | 2000-02-23 | — | — | EP | disclosed |
| US-5830901-A | Tetrahydropyridinylmethyl derivatives of pyrrolo 2,3-B!pyridine | MERCH SHARP & DOHME LTD | 1998-11-03 | — | — | US | disclosed |
| EP-0775138-A1 | TETRAHYDROPYRIDINYLMETHYL DERIVATIVES OF PYRROLO 2,3-b]PYRIDINE | MERCK SHARP & DOHME LTD. (GB) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005200-A1 | TETRAHYDROPYRIDINYLMETHYL DERIVATIVES OF PYRROLO[2,3-b]PYRIDINE | MERCK SHARP & DOHME LIMITED (GB) | 1996-02-22 | — | — | WO | disclosed |