Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8429503 | 1.00 | KDM4E (0.64) | KDM4ESMN1; SMN2RAB9ANPC1KMT2A | |
| Hydrochloric Acid SCHEMBL8428831 | 0.98 | KDM4E (0.66) | KDM4ESMN1; SMN2RAB9ANPC1KMT2A | |
| Hydrochloric Acid SCHEMBL8428835 | 0.98 | KDM4E (0.66) | KDM4ESMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL8427008 | 0.92 | KDM4E (0.62) | KDM4ESMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL8427010 | 0.92 | KDM4E (0.62) | KDM4ESMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL8429499 | 0.92 | KDM4E (0.62) | KDM4ESMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL8429502 | 0.92 | KDM4E (0.62) | KDM4ESMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL8128381 | 0.90 | SMN1; SMN2 (0.60) | KDM4ESMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL8128377 | 0.90 | SMN1; SMN2 (0.60) | KDM4ESMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL8426889 | 0.90 | KDM4E (0.60) | KDM4ESMN1; SMN2RAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861407-A | Tetrahydropyridine derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME, LTD. (GB) | 1999-01-19 | — | — | US | claimed |
| US-5861407-A | Tetrahydropyridine derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME, LTD. (GB) | 1999-01-19 | — | — | US | disclosed |
| EP-0757686-A1 | BENZOFURAN DERIVATIVES AS D 4? RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029911-A1 | BENZOFURAN DERIVATIVES AS D4 RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-11-09 | — | — | WO | disclosed |
| US-4169200-A | HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1979-09-25 | — | — | US | disclosed |