Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PYGM | P11217 | 4/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8128991 | 1.00 | TRPV1 (0.35) | TRPV1EGFRKDRPYGMHDAC8 | |
| SCHEMBL8126483 | 0.87 | HDAC8 (0.48) | HDAC8HDAC6KDM4EALDH1A1MAPT | |
| SCHEMBL8126478 | 0.87 | HDAC8 (0.48) | HDAC8HDAC6KDM4EALDH1A1MAPT | |
| SCHEMBL8133214 | 0.85 | HDAC8 (0.48) | HDAC8HDAC6KDM4EALDH1A1MAPT | |
| SCHEMBL8133217 | 0.85 | HDAC8 (0.48) | HDAC8HDAC6KDM4EALDH1A1MAPT | |
| SCHEMBL8125056 | 0.84 | HTR2A (0.41) | HDAC8SIGMAR1HDAC6 | |
| SCHEMBL8125059 | 0.84 | HTR2A (0.41) | HDAC8SIGMAR1HDAC6 | |
| SCHEMBL8922063 | 0.83 | ACHE (0.41) | TRPV1LTA4HEPHX2 | |
| SCHEMBL8133359 | 0.83 | HDAC8 (0.40) | EGFRHDAC8SIGMAR1 | |
| SCHEMBL8133357 | 0.83 | HDAC8 (0.40) | EGFRHDAC8SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664291-B1 | PYRIMIDINE COMPOUND | UBE INDUSTRIES (JP) | 2000-07-19 | — | — | EP | disclosed |
| US-5610303-A | MONOAMIDE OXIDASE INHIBITORS | UBE INDUSTRIES, LTD. (JP) | 1997-03-11 | — | — | US | disclosed |
| EP-0664291-A1 | PYRIMIDINE COMPOUND | UBE INDUSTRIES, LTD. (JP) | 1995-07-26 | — | — | EP | disclosed |