Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.54 |
| ▸ | HTR1D | P28221 | 11/20 | 0.54 |
| ▸ | HTR1B | P28222 | 11/20 | 0.54 |
| ▸ | HTR2C | P28335 | 5/20 | 0.54 |
| ▸ | HTR6 | P50406 | 4/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | GOT1 | P17174 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8120074 | 0.83 | HTR1D (0.57) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL8130976 | 0.81 | HTR1A (0.58) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL8148868 | 0.81 | HTR1D (0.72) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL8134212 | 0.80 | HTR2C (0.57) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL8130299 | 0.80 | HTR1D (0.51) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL8135632 | 0.80 | TRPV1 (0.55) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL27807534 | 0.78 | TRPV1 (0.67) | HTR2C | |
| SCHEMBL8128102 | 0.78 | HTR1D (0.50) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL8134852 | 0.77 | HTR1D (0.53) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL8122186 | 0.77 | MEN1 (0.60) | HTR1AHTR1DHTR1BHTR2CHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159979-A | Bicyclic aryl or a bicyclic heterocyclic ring containing compounds having a combined 5HT1A, 5HT1B and 5HT1D receptor antagonistic activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-12-12 | — | — | US | claimed |
| EP-0975614-A1 | A BICYCLIC ARYL OR A BICYCLIC HETEROCYCLIC RING CONTAINING COMPOUNDS HAVING A COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | claimed |
| WO-1998047885-A1 | A BICYCLIC ARYL OR A BICYCLIC HETEROCYCLIC RING CONTAINING COMPOUNDS HAVING A COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-10-29 | — | — | WO | claimed |
| US-6159979-A | Bicyclic aryl or a bicyclic heterocyclic ring containing compounds having a combined 5HT1A, 5HT1B and 5HT1D receptor antagonistic activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-12-12 | — | — | US | disclosed |
| EP-0975614-A1 | A BICYCLIC ARYL OR A BICYCLIC HETEROCYCLIC RING CONTAINING COMPOUNDS HAVING A COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998047885-A1 | A BICYCLIC ARYL OR A BICYCLIC HETEROCYCLIC RING CONTAINING COMPOUNDS HAVING A COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-10-29 | — | — | WO | disclosed |