Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11746341 | 0.72 | MEN1 (0.48) | MEN1KMT2ACDC25BBCL2MCL1 | |
| SCHEMBL9547857 | 0.70 | SMN1; SMN2 (0.44) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL9171969 | 0.69 | NPC1 (0.66) | MEN1KMT2ACDC25BBCL2MCL1 | |
| Anthraquinone SCHEMBL27593709 | 0.69 | MEN1 (0.71) | MEN1KMT2ACDC25BBCL2MCL1 | |
| Anthraquinone SCHEMBL28260408 | 0.68 | MEN1 (0.92) | MEN1KMT2ACDC25BBCL2MCL1 | |
| SCHEMBL31674878 | 0.68 | NPC1 (0.63) | MEN1KMT2ACDC25BBCL2MCL1 | |
| SCHEMBL7791837 | 0.68 | NPC1 (0.63) | MEN1KMT2ACDC25BBCL2MCL1 | |
| SCHEMBL8125338 | 0.68 | MEN1 (0.43) | MEN1KMT2ACDC25BBCL2MCL1 | |
| SCHEMBL457917 | 0.67 | CYP1A2 (0.33) | MEN1KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL14874534 | 0.67 | MEN1 (0.67) | MEN1KMT2ACDC25BBCL2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |