Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 20/20 | 0.64 |
| ▸ | HTR2A | P28223 | 17/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.64 |
| ▸ | HTR2B | P41595 | 16/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7078076 | 0.86 | HTR2C (0.64) | HTR2CHTR2ACYP1A2HTR2BKDM4E | |
| SCHEMBL7374660 | 0.85 | HTR2C (0.65) | HTR2CHTR2ACYP1A2HTR2BKDM4E | |
| SCHEMBL8113401 | 0.85 | HTR2C (0.58) | HTR2CHTR2ACYP1A2HTR2BKDM4E | |
| SCHEMBL7085815 | 0.84 | HTR2C (0.62) | HTR2CHTR2ACYP1A2HTR2BMEN1 | |
| SCHEMBL7081852 | 0.83 | HTR2C (0.59) | HTR2CHTR2ACYP1A2HTR2BKDM4E | |
| SCHEMBL8127392 | 0.81 | HTR2C (0.57) | HTR2CHTR2ACYP1A2HTR2BKDM4E | |
| SCHEMBL7473419 | 0.80 | HTR2C (0.59) | HTR2CHTR2ACYP1A2HTR2BCYP2C9 | |
| SCHEMBL7041601 | 0.79 | HTR2C (0.55) | HTR2CHTR2ACYP1A2HTR2BKDM4E | |
| SCHEMBL7079140 | 0.78 | HTR2C (0.59) | HTR2CHTR2ACYP1A2HTR2BKDM4E | |
| SCHEMBL7376883 | 0.78 | HTR2C (0.60) | HTR2CHTR2ACYP1A2HTR2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808312-B1 | INDOLE DERIVATIVES AS 5-HT RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM PLC (GB) | 2000-11-02 | — | — | EP | claimed |