Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 20/20 | 0.59 |
| ▸ | HTR2A | P28223 | 19/20 | 0.59 |
| ▸ | HTR2B | P41595 | 18/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | HTR6 | P50406 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7376883 | 0.90 | HTR2C (0.60) | HTR2CHTR2AHTR2BCYP2C9HTR6 | |
| SCHEMBL8129227 | 0.80 | HTR2C (0.64) | HTR2CHTR2AHTR2BCYP2C9CYP1A2 | |
| SCHEMBL7085815 | 0.77 | HTR2C (0.62) | HTR2CHTR2AHTR2BCYP2C9CYP1A2 | |
| SCHEMBL7374660 | 0.74 | HTR2C (0.65) | HTR2CHTR2AHTR2BCYP2C9CYP1A2 | |
| SCHEMBL8113401 | 0.74 | HTR2C (0.58) | HTR2CHTR2AHTR2BCYP2C9CYP1A2 | |
| SCHEMBL7566491 | 0.74 | HTR2C (0.58) | HTR2CHTR2AHTR2BCYP2C9HTR6 | |
| SCHEMBL7078076 | 0.74 | HTR2C (0.64) | HTR2CHTR2AHTR2BCYP2C9CYP1A2 | |
| Sb-243213 SCHEMBL677610 | 0.73 | HTR2C (1.00) | HTR2CHTR2AHTR2BCYP2C9HTR6 | |
| Sb-243213 SCHEMBL31060820 | 0.73 | HTR2C (1.00) | HTR2CHTR2AHTR2BCYP2C9HTR6 | |
| Sb-243213 SCHEMBL29697170 | 0.73 | HTR2C (1.00) | HTR2CHTR2AHTR2BCYP2C9HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912554-B1 | INDOLINE DERIVATIVES USEFUL AS 5-HT-2C RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2002-11-27 | — | — | EP | disclosed |
| US-6369060-B1 | CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS ANXIETY; 5-METHYL-6-TRIFLUOROMETHYL-1-(6-(2-METHYLPYRIDIN-3-YLOXY)-PYRIDIN-3-YL CARBAMOYL)INDOLINE AND 5-METHYL-1-(6-(2-METHYLPYRIDIN-3-YLOXY) -PYRIDAZIN-3-YLCARBAMOYL)-6-TRIFLUOROMETHYLINDOLINE | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-04-09 | — | — | US | disclosed |