Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 4/20 | 0.41 |
| ▸ | TOP1 | P11387 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8120307 | 0.92 | TOP2A (0.40) | TOP2ATOP1KCNH2ALDH1A1POLB | |
| SCHEMBL8134768 | 0.91 | KCNH2 (0.43) | TOP2AKCNH2ALDH1A1POLBOPRM1 | |
| SCHEMBL8119666 | 0.91 | KCNH2 (0.43) | TOP2AKCNH2ALDH1A1POLBOPRM1 | |
| SCHEMBL8901293 | 0.90 | ALDH1A1 (0.51) | TOP2ATOP1KCNH2ALDH1A1POLB | |
| SCHEMBL8565145 | 0.90 | ALDH1A1 (0.51) | TOP2ATOP1KCNH2ALDH1A1POLB | |
| SCHEMBL8901278 | 0.90 | ALDH1A1 (0.51) | TOP2ATOP1KCNH2ALDH1A1POLB | |
| SCHEMBL8122322 | 0.90 | KCNH2 (0.45) | TOP2AKCNH2ALDH1A1POLBOPRM1 | |
| SCHEMBL8136563 | 0.88 | KCNH2 (0.43) | TOP2AKCNH2ALDH1A1POLBOPRM1 | |
| SCHEMBL8138031 | 0.87 | KCNH2 (0.40) | TOP2ATOP1KCNH2ALDH1A1POLB | |
| SCHEMBL8129317 | 0.85 | ALDH1A1 (0.48) | TOP2ATOP1KCNH2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0401623-B1 | Process for the preparation of 7-(3-amino- and 3-aminomethyl-1-pyrrolidinyl)-3-quinolinonecarboxylic and -naphthyridinonecarboxylic acids | BAYER AG (DE) | 2000-01-26 | — | — | EP | disclosed |
| EP-0401623-A1 | Process for the preparation of 7-(3-amino- and 3-aminomethyl-1-pyrrolidinyl)-3-quinolinonecarboxylic and -naphthyridinonecarboxylic acids | BAYER AG (DE) | 1990-12-12 | — | — | EP | disclosed |