Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GLP1R | P43220 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8138168 | 0.90 | NPC1 (0.35) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8142985 | 0.88 | GLP1R (0.35) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8129358 | 0.86 | MAPT (0.34) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8129486 | 0.86 | SMN1; SMN2 (0.34) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8143187 | 0.85 | MAPK8 (0.42) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL8135069 | 0.82 | SMN1; SMN2 (0.32) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8139117 | 0.82 | CDC7 (0.43) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL8137173 | 0.81 | NPSR1 (0.40) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL8144240 | 0.79 | NPC1 (0.37) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL8129645 | 0.78 | HPGD (0.35) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808318-B1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LAB (US) | 2000-06-28 | — | — | EP | disclosed |
| US-5597823-A | TREATING BENIGN PROSTATIC HYPERPLASIA | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |
| WO-1996022992-A1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-08-01 | — | — | WO | disclosed |