Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8139117 | 0.88 | CDC7 (0.43) | NPSR1CYP1A2CYP2C9KMT2AMEN1 | |
| SCHEMBL8127687 | 0.88 | LMNA (0.41) | NPSR1CYP1A2GAACYP3A4CYP2C9 | |
| SCHEMBL8144214 | 0.86 | NPSR1 (0.58) | NPSR1CYP1A2GAACYP3A4CYP2C9 | |
| SCHEMBL8144240 | 0.85 | NPC1 (0.37) | NPSR1CYP1A2CYP2C9KMT2AMEN1 | |
| SCHEMBL8139144 | 0.83 | ALDH1A1 (0.41) | NPSR1CYP1A2GAACYP3A4CYP2C9 | |
| SCHEMBL8933479 | 0.81 | NPSR1 (0.53) | NPSR1CYP1A2GAACYP3A4CYP2C9 | |
| SCHEMBL8128482 | 0.81 | ALDH1A1 (0.46) | NPSR1CYP1A2GAACYP3A4CYP2C9 | |
| SCHEMBL8129643 | 0.81 | ALDH1A1 (0.35) | NPSR1CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL8138168 | 0.80 | NPC1 (0.35) | NPSR1CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL8142985 | 0.79 | GLP1R (0.35) | NPSR1GAACYP2C9KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808318-B1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LAB (US) | 2000-06-28 | — | — | EP | disclosed |