Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 17/20 | 0.58 |
| ▸ | EBP | Q15125 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.57 |
| ▸ | MTOR | P42345 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101149 | 0.90 | SIGMAR1 (0.56) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL240450 | 0.83 | SIGMAR1 (0.68) | SIGMAR1EBPTP53CYP1A2CYP3A4 | |
| SCHEMBL23770525 | 0.81 | SIGMAR1 (0.50) | SIGMAR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL31052615 | 0.79 | SIGMAR1 (0.60) | SIGMAR1EBPTP53CYP1A2CYP3A4 | |
| SCHEMBL18192167 | 0.79 | SIGMAR1 (0.60) | SIGMAR1EBPTP53CYP1A2CYP3A4 | |
| SCHEMBL23770526 | 0.79 | SIGMAR1 (0.47) | SIGMAR1EBPTP53CYP1A2CYP3A4 | |
| SCHEMBL8260614 | 0.79 | KDM1A (0.51) | SIGMAR1DRD2CYP2C19 | |
| SCHEMBL2758036 | 0.79 | SIGMAR1 (0.70) | SIGMAR1EBPTP53CYP1A2CYP3A4 | |
| SCHEMBL30291382 | 0.77 | SIGMAR1 (0.58) | SIGMAR1EBPTP53CYP1A2CYP3A4 | |
| SCHEMBL11704179 | 0.77 | SIGMAR1 (0.58) | SIGMAR1EBPTP53CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7884107-B2 | Human Double Minute 2 (HDM2) protein inhibitors; anticancer agents | MERCK (US) | 2011-02-08 | — | — | US | disclosed |
| US-20080004287-A1 | Substituted Piperidines that Increase P53 Activity and the Uses Thereof | SCHERING CORPORATION | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004287-A1 | Substituted Piperidines that Increase P53 Activity and the Uses Thereof | TP53, MDM2, TP53BP1 | SIGMAR1 4442/4885EBP 1825/4885TP53 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.