Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 15/20 | 0.60 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | HTR1D | P28221 | 2/20 | 0.59 |
| ▸ | HTR1B | P28222 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 12/20 | 0.53 |
| ▸ | HTR2B | P41595 | 7/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8126725 | 0.89 | SLC2A1 (0.68) | HTR2CSLC2A1HTR1AHTR1DHTR1B | |
| SCHEMBL8151359 | 0.83 | SLC2A1 (0.62) | HTR2CSLC2A1HTR1AHTR1DHTR1B | |
| SCHEMBL8117432 | 0.82 | SLC2A1 (0.66) | HTR2CSLC2A1HTR1AHTR1DHTR1B | |
| SCHEMBL8136220 | 0.82 | SLC2A1 (0.63) | HTR2CSLC2A1HTR1AHTR1DHTR1B | |
| SCHEMBL8134911 | 0.82 | SLC2A1 (0.63) | HTR2CSLC2A1HTR1AHTR1DHTR1B | |
| SCHEMBL8124544 | 0.82 | HTR2C (0.74) | HTR2CSLC2A1HTR1AHTR1DHTR1B | |
| SCHEMBL8128490 | 0.82 | SLC2A1 (0.66) | HTR2CSLC2A1HTR1AHTR1DHTR1B | |
| SCHEMBL27542467 | 0.81 | HTR1D (0.63) | HTR2CSLC2A1HTR1AHTR1DHTR1B | |
| SCHEMBL8118623 | 0.81 | SLC2A1 (0.62) | HTR2CSLC2A1HTR1AHTR1DHTR1B | |
| SCHEMBL8132288 | 0.81 | SLC2A1 (0.81) | HTR2CSLC2A1HTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975593-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | claimed |
| WO-1998050358-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | claimed |
| EP-0975593-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998050358-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |