Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 2/20 | 0.66 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | HTR1D | P28221 | 2/20 | 0.54 |
| ▸ | HTR1B | P28222 | 2/20 | 0.54 |
| ▸ | HTR2C | P28335 | 11/20 | 0.52 |
| ▸ | HTR2A | P28223 | 9/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8129371 | 0.89 | SLC2A1 (0.63) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8118623 | 0.86 | SLC2A1 (0.62) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8135507 | 0.86 | SLC2A1 (0.69) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8131066 | 0.86 | SLC2A1 (0.71) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8132574 | 0.85 | SLC2A1 (0.65) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8132681 | 0.84 | SLC2A1 (0.64) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8126263 | 0.84 | SLC2A1 (0.71) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8156195 | 0.84 | SLC2A1 (0.71) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8151359 | 0.83 | SLC2A1 (0.62) | SLC2A1HTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL8126878 | 0.82 | SLC2A1 (0.68) | SLC2A1HTR1AHTR1DHTR1BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975593-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998050358-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |