O,O'-Dimethylcaffeic Acid

O,O'-Dimethylcaffeic Acid

SCHEMBL81318

COc1ccc(C=CC(=O)O)cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 1.00
ALDH1A1 P00352 4/20 1.00
HPGD P15428 2/20 1.00
HSD17B10 Q99714 2/20 1.00
SMN1; SMN2 Q16637 2/20 1.00
ALOX15 P16050 1/20 1.00
MAPK1 P28482 1/20 1.00
SNCA P37840 2/20 0.76
PKM P14618 2/20 0.76
CA12 O43570 1/20 0.76
CA1 P00915 1/20 0.76
CA2 P00918 1/20 0.76
CA3 P07451 1/20 0.76
CSNK2A2 P19784 1/20 0.76
CA4 P22748 1/20 0.76
CA6 P23280 1/20 0.76
CA5A P35218 1/20 0.76
CA7 P43166 1/20 0.76
CSNK2B P67870 1/20 0.76
CSNK2A1 P68400 1/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
O,O'-Dimethylcaffeic Acid SCHEMBL29636389 1.00 KDM4E (1.00) KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2
O,O'-Dimethylcaffeic Acid SCHEMBL81317 1.00 KDM4E (1.00) KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2
O,O'-Dimethylcaffeic Acid SCHEMBL27858762 0.98 KDM4E (0.97) KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2
O,O'-Dimethylcaffeic Acid SCHEMBL27858763 0.98 KDM4E (0.97) KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2
O,O'-Dimethylcaffeic Acid SCHEMBL28025225 0.98 KDM4E (0.97) KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2
O,O'-Dimethylcaffeic Acid SCHEMBL8367702 0.92 KDM4E (0.85) KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2
SCHEMBL28950903 0.92 KDM4E (0.84) KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2
SCHEMBL13039663 0.90 KDM4E (0.82) KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2
SCHEMBL2678970 0.90 KDM4E (0.82) KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2
SCHEMBL25203581 0.89 ABCG2 (0.86) KDM4EALDH1A1HPGDHSD17B10SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1325 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122079891-A Forsyqinlingine C derivative and preparation method and application thereof 2026-05-26 CN claimed
US-20260015485-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE TOYO TIRE CORPORATION (JP) 2026-01-15 US claimed
US-20260015495-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE TOYO TIRE CORPORATION (JP) 2026-01-15 US claimed
US-20260015491-A1 RUBBER COMPOSITION FOR TIRE SIDE WALL AND PNEUMATIC TIRE TOYO TIRE CORPORATION (JP) 2026-01-15 US claimed
US-20260015494-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE TOYO TIRE CORPORATION (JP) 2026-01-15 US claimed
US-20260015493-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE TOYO TIRE CORPORATION (JP) 2026-01-15 US claimed
US-20260015496-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE TOYO TIRE CORPORATION (JP) 2026-01-15 US claimed
EP-4678411-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE Toyo Tire Corporation (JP) 2026-01-14 EP claimed
EP-4678408-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE Toyo Tire Corporation (JP) 2026-01-14 EP claimed
EP-4678410-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE Toyo Tire Corporation (JP) 2026-01-14 EP claimed
WO-1995018606-A1 CURCUMIN, ANALOGUES OF CURCUMIN AND NOVEL USES THEREOF RESEARCH DEVELOPMENT FOUNDATION (US) 1995-07-13 WO claimed
EP-0452504-B1 N-(3',4'-DIMETHOXYCINNAMOYL)ANTHRANILIC ACID KOHJIN CO (JP) 1994-10-12 EP claimed
US-5223639-A PROCESS FOR PRODUCING N-(3', 4'-DIMETHOXYCINNAMOYL)-ANTHRANILIC ACID KOHJIN CO., LTD. (JP) 1993-06-29 US claimed
EP-0452504-A1 N-(3',4'-DIMETHOXYCINNAMOYL)ANTHRANILIC ACID KOHJIN CO. Ltd. (JP) 1991-10-23 EP claimed
EP-0166542-B1 TRITERPENYL ESTERS OF ORGANIC ACIDS, PROCESS FOR THEIR PRODUCTION, AND HYPOLIPIDEMIC AGENTS COMPOSED OF THEM AMANO PHARMACEUTICAL CO., LTD. (JP) 1990-08-08 EP claimed
EP-0174064-B1 COMPOSITIONS AND COMPOUNDS FOR THE TREATMENT OF PROSTATIC ADENOMA INVERNI DELLA BEFFA S.P.A. (IT) 1989-12-06 EP claimed
US-4748161-A Triterpenyl esters of organic acids and hypolipidemic agents composed of them AMANO PHARMACEUTICAL CO., LTD. (JP) 1988-05-31 US claimed
EP-0152799-B1 COMPOUNDS HAVING PERIPHERAL CALCIUM ANTAGONIST, ANTICONVULSIVE AND EUMETABOLIC ACTIVITY, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PULITZER ITALIANA S.p.A. (IT) 1987-10-28 EP claimed
EP-0166542-A2 Triterpenyl esters of organic acids, process for their production, and hypolipidemic agents composed of them AMANO PHARMACEUTICAL CO., LTD. (JP) 1986-01-02 EP claimed
EP-0152799-A1 Compounds having peripheral calcium antagonist, anticonvulsive and eumetabolic activity, processes for the preparation thereof and pharmaceutical compositions containing them PULITZER ITALIANA S.p.A. (IT) 1985-08-28 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260015485-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE RIF1, RER1, HRH1 KDM4E 2828/4885ALDH1A1 3089/4885HPGD 1928/4885
US-20260015496-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE RIF1, NR2E1, RAD51 KDM4E 1528/4885ALDH1A1 3161/4885HPGD 2837/4885
US-20260015493-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE RIF1, NR2E1, RAD51 KDM4E 1674/4885ALDH1A1 2094/4885HPGD 1974/4885
US-20260015491-A1 RUBBER COMPOSITION FOR TIRE SIDE WALL AND PNEUMATIC TIRE RIF1, TELO2, THOC2 KDM4E 1769/4885ALDH1A1 3832/4885HPGD 3842/4885
US-20260015495-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE RIF1, CCT4, NR2E1 KDM4E 1923/4885ALDH1A1 2789/4885HPGD 3320/4885
US-20260015494-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE RIF1, CCT4, NR2E1 KDM4E 3124/4885ALDH1A1 2734/4885HPGD 2701/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.