Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8131761 | 0.87 | HTR2A (0.53) | HTR2ASIGMAR1TMEM97 | |
| SCHEMBL8137489 | 0.85 | HTR2A (0.54) | HTR2A | |
| SCHEMBL24540179 | 0.79 | LSS (0.47) | HTR2ASIGMAR1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL2277992 | 0.78 | HTR2C (0.48) | HTR2A | |
| SCHEMBL8143910 | 0.78 | PDE4B (0.52) | SIGMAR1 | |
| SCHEMBL25722721 | 0.77 | HTR2A (0.59) | HTR2ASIGMAR1 | |
| SCHEMBL23326127 | 0.77 | HTR2A (1.00) | HTR2A | |
| SCHEMBL23326129 | 0.77 | HTR2A (1.00) | HTR2A | |
| SCHEMBL29775391 | 0.77 | HTR2A (1.00) | HTR2A | |
| SCHEMBL23326224 | 0.77 | HTR2A (1.00) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037876-A1 | BIPHENYL DERIVATIVES AS PHARMACEUTICALS | Novartis AG (CH) | 2000-09-27 | — | — | EP | claimed |
| WO-1999023073-A1 | BIPHENYL DERIVATIVES AS PHARMACEUTICALS | NOVARTIS AG (CH) | 1999-05-14 | — | — | WO | claimed |
| EP-1037876-A1 | BIPHENYL DERIVATIVES AS PHARMACEUTICALS | Novartis AG (CH) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999023073-A1 | BIPHENYL DERIVATIVES AS PHARMACEUTICALS | NOVARTIS AG (CH) | 1999-05-14 | — | — | WO | disclosed |