Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2277992 | 0.92 | HTR2C (0.48) | HTR2AHTR2CDRD2 | |
| SCHEMBL8131998 | 0.85 | HTR2A (0.62) | HTR2A | |
| SCHEMBL12852526 | 0.82 | HTR2A (0.56) | HTR2AHTR2CDRD2 | |
| SCHEMBL25722721 | 0.81 | HTR2A (0.59) | HTR2A | |
| SCHEMBL12396714 | 0.76 | MEN1 (0.46) | — | |
| SCHEMBL26473316 | 0.74 | HTR2A (0.67) | HTR2AHTR2C | |
| SCHEMBL26473311 | 0.74 | HTR2A (0.67) | HTR2AHTR2C | |
| SCHEMBL8156328 | 0.74 | HTR2A (0.48) | HTR2AHTR2CDRD2KCNH2 | |
| SCHEMBL28740554 | 0.74 | BRD4 (0.52) | HTR2AHTR2CDRD2KCNH2 | |
| SCHEMBL13416040 | 0.73 | DRD2 (0.61) | HTR2AHTR2CDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037876-A1 | BIPHENYL DERIVATIVES AS PHARMACEUTICALS | Novartis AG (CH) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999023073-A1 | BIPHENYL DERIVATIVES AS PHARMACEUTICALS | NOVARTIS AG (CH) | 1999-05-14 | — | — | WO | disclosed |