SCHEMBL8133016

SCHEMBL8133016

CSc1nc(SCc2ccccc2)nc(N)c1C(C)C

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.56
RAB9A P51151 5/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
NPC1 O15118 2/20 0.50
CXCR2 P25025 4/20 0.47
PPARG P37231 1/20 0.46
ALOX15 P16050 1/20 0.43
POLB P06746 1/20 0.41
HPGD P15428 1/20 0.41
ALDH1A1 P00352 1/20 0.41
TSHR P16473 1/20 0.41
NFKB1 P19838 1/20 0.41
NFKB2 Q00653 1/20 0.41
RELA Q04206 1/20 0.41
HSD17B10 Q99714 1/20 0.41
PAK4 O96013 2/20 0.40
CX3CR1 P49238 2/20 0.40
KDM1A O60341 1/20 0.40
ABCB1 P08183 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6641821 0.82 POLB (0.54) HSP90AA1RAB9ASMN1; SMN2NPC1CXCR2
SCHEMBL6640181 0.82 PAK4 (0.52) HSP90AA1RAB9ASMN1; SMN2NPC1CXCR2
SCHEMBL5494013 0.75 RAB9A (0.60) HSP90AA1RAB9ASMN1; SMN2NPC1CXCR2
SCHEMBL5450296 0.74 RAB9A (0.68) HSP90AA1RAB9ASMN1; SMN2NPC1CXCR2
SCHEMBL8124942 0.74 HSP90AA1 (0.50) HSP90AA1RAB9ASMN1; SMN2NPC1CXCR2
SCHEMBL8125458 0.71 HSP90AA1 (0.44) HSP90AA1RAB9ASMN1; SMN2NPC1CXCR2
SCHEMBL8125405 0.71 HSP90AA1 (0.44) HSP90AA1RAB9ASMN1; SMN2NPC1CXCR2
SCHEMBL8125824 0.70 HSP90AA1 (0.43) HSP90AA1RAB9ASMN1; SMN2NPC1CXCR2
SCHEMBL13752162 0.70 RAB9A (0.70) HSP90AA1RAB9ASMN1; SMN2NPC1CXCR2
SCHEMBL8138707 0.69 RAB9A (0.73) HSP90AA1RAB9ASMN1; SMN2NPC1CXCR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1309656-A Alkylthio alpha-substituted pyrimidine compounds UPJOHN CO (US) 2001-08-22 CN disclosed
US-6124306-A Thioalkyl alpha substituted pyrimidine compounds PHARMACIA & UPJOHN COMPANY (US) 2000-09-26 US disclosed
EP-1034167-A1 ALPHA-ALKYLTHIO SUBSTITUTED PYRIMIDINE ETHERS AND THIOETHERS AS VIRAL REVERSE TRANSCRIPTASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 2000-09-13 EP disclosed
WO-1999019304-A9 ALPHA-ALKYLTHIO SUBSTITUTED PYRIMIDINE ETHERS AND THIOETHERS AS VIRAL REVERSE TRANSCRIPTASE INHIBITORS UPJOHN CO (US) 1999-07-08 WO disclosed
WO-1999019304-A2 ALPHA-ALKYLTHIO SUBSTITUTED PYRIMIDINE ETHERS AND THIOETHERS AS VIRAL REVERSE TRANSCRIPTASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1999-04-22 WO disclosed