Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 17/20 | 1.00 |
| ▸ | MTNR1B | P49286 | 15/20 | 0.64 |
| ▸ | NQO2 | P16083 | 1/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8143092 | 0.89 | MTNR1A (0.81) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8137636 | 0.88 | MTNR1A (0.79) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8137642 | 0.87 | MTNR1A (0.78) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8152799 | 0.87 | MTNR1A (0.78) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8152291 | 0.87 | MTNR1A (0.78) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8136431 | 0.87 | MTNR1A (0.78) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8134907 | 0.86 | MTNR1A (0.76) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8150330 | 0.85 | MTNR1A (0.74) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8128204 | 0.85 | MTNR1A (0.74) | MTNR1AMTNR1BNQO2ROCK1HTR2C | |
| SCHEMBL7017774 | 0.85 | MTNR1A (0.74) | MTNR1AMTNR1BNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737685-B1 | Pyridine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-07-19 | — | — | EP | claimed |
| EP-0737685-B1 | Pyridine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-07-19 | — | — | EP | disclosed |
| US-5714495-A | ANXIOLYTIC AGENTS, MELATONIN RECEPTORS FOR TREATING PSYCHOLOGICAL DISORDERS AND ANALGESICS, SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-02-03 | — | — | US | disclosed |
| EP-0737685-A1 | Pyridine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-10-16 | — | — | EP | disclosed |