Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 5/20 | 0.40 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.39 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8135675 | 1.00 | EPHX2 (0.45) | EPHX2LMNATBXA2RTBXAS1MEN1 | |
| SCHEMBL8142846 | 0.81 | MEN1 (0.46) | EPHX2LMNATBXA2RTBXAS1MEN1 | |
| SCHEMBL8142850 | 0.81 | MEN1 (0.46) | EPHX2LMNATBXA2RTBXAS1MEN1 | |
| SCHEMBL8127023 | 0.79 | QPCTL (0.38) | LMNAP2RX1TMPRSS4QPCTLMAPT | |
| SCHEMBL8127022 | 0.79 | QPCTL (0.38) | LMNAP2RX1TMPRSS4QPCTLMAPT | |
| SCHEMBL8129144 | 0.78 | P2RX1 (0.39) | LMNAMEN1KMT2AP2RX1CXCR3 | |
| SCHEMBL8129143 | 0.78 | P2RX1 (0.39) | LMNAMEN1KMT2AP2RX1CXCR3 | |
| SCHEMBL23736048 | 0.74 | EPHX2 (0.75) | EPHX2MEN1KMT2ASMN1; SMN2CXCR3 | |
| SCHEMBL18789617 | 0.74 | EPHX2 (0.52) | EPHX2LMNAMEN1KMT2AHTT | |
| SCHEMBL5598039 | 0.74 | EPHX2 (0.75) | EPHX2MEN1KMT2ASMN1; SMN2CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147098-A | USEFUL IN THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM, PULMONARY SYSTEM, GASTROINTESTINAL SYSTEM AND ENDOCRINOLOGIC SYSTEM | NOVO NORDISK A/S (DK) | 2000-11-14 | — | — | US | disclosed |