Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 3/20 | 0.62 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.62 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | CTSG | P08311 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8135760 | 1.00 | KCNA3 (0.62) | KCNA3KCNN4MMP2CTSGCMA1 | |
| SCHEMBL14502625 | 0.87 | KCNN4 (0.55) | KCNA3KCNN4MMP2GAALMNA | |
| SCHEMBL28665779 | 0.79 | KCNA3 (0.89) | KCNA3KCNN4MMP2CTSGCMA1 | |
| SCHEMBL3034555 | 0.77 | KCNA3 (1.00) | KCNA3KCNN4MMP2CTSGCMA1 | |
| SCHEMBL28973111 | 0.76 | KCNN4 (0.62) | KCNA3KCNN4MMP2CTSGCMA1 | |
| SCHEMBL29754844 | 0.76 | KCNN4 (0.62) | KCNA3KCNN4MMP2CTSGCMA1 | |
| SCHEMBL14621111 | 0.75 | KCNA3 (0.68) | KCNA3KCNN4MMP2CTSGCMA1 | |
| SCHEMBL14280956 | 0.71 | KCNA3 (0.59) | KCNA3KCNN4MMP2CTSGCMA1 | |
| SCHEMBL768700 | 0.71 | KCNN4 (0.67) | KCNA3KCNN4MMP2GAALMNA | |
| SCHEMBL2514016 | 0.71 | KCNN4 (0.55) | KCNA3KCNN4MMP2GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019380-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999016753-A2 | TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-04-08 | — | — | WO | disclosed |