⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31547630 | 1.00 | — | — | |
| SCHEMBL29727517 | 0.77 | LMNA (0.52) | — | |
| SCHEMBL871319 | 0.77 | LMNA (0.52) | — | |
| SCHEMBL30406224 | 0.72 | LMNA (0.39) | — | |
| SCHEMBL2947533 | 0.72 | LMNA (0.39) | — | |
| SCHEMBL29169316 | 0.69 | — | — | |
| SCHEMBL1425201 | 0.69 | — | — | |
| SCHEMBL316983 | 0.69 | HTT (0.44) | — | |
| SCHEMBL31088294 | 0.69 | HTT (0.44) | — | |
| SCHEMBL19922200 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763031-B1 | PIPERAZINE DERIVATIVES AS 5HT1A ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 2000-05-10 | — | — | EP | claimed |
| US-5723464-A | CENTRAL NERVOUS SYSTEM DISORDERS, ANXIETY OR DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-03 | — | — | US | claimed |
| EP-0763031-A1 | PIPERAZINE DERIVATIVES AS 5HT1A ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1997-03-19 | — | — | EP | claimed |
| WO-1995033743-A1 | PIPERAZINE DERIVATIVES AS 5HT1A ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1995-12-14 | — | — | WO | claimed |
| WO-2025073792-A1 | WRN INHIBITORY COMPOUNDS | FORX THERAPEUTICS AG (CH) | 2025-04-10 | — | — | WO | disclosed |
| US-10160695-B2 | Synthesis of meta-substituted [18F]-3-fluoro-4-aminopyridines by direct radiofluorination of pyridine N-oxides | THE UNIVERSITY OF CHICAGO (US) | 2018-12-25 | — | — | US | disclosed |
| US-20170355648-A1 | SYNTHESIS OF META-SUBSTITUTED [18F]-3-FLUORO-4-AMINOPYRIDINES BY DIRECT RADIOFLUORINATION OF PYRIDINE N-OXIDES | THE UNIVERSITY OF CHICAGO | 2017-12-14 | — | — | US | disclosed |
| CN-102271682-B | Be used for the treatment of the P2X of pain 3receptor antagonist | MERCK SHARP & DOHME CORP. (US) | 2015-12-16 | — | — | CN | disclosed |
| CN-105101800-A | Heterocyclic compounds as pesticides | BAYER CROPSCIENCE AG | 2015-11-25 | — | — | CN | disclosed |
| EP-2736330-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2014-06-04 | — | — | EP | disclosed |
| WO-2013019682-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2013-02-07 | — | — | WO | disclosed |
| EP-0763031-B1 | PIPERAZINE DERIVATIVES AS 5HT1A ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 2000-05-10 | — | — | EP | disclosed |
| US-5723464-A | CENTRAL NERVOUS SYSTEM DISORDERS, ANXIETY OR DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-03 | — | — | US | disclosed |
| WO-1997040038-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GMBH (DE) | 1997-10-30 | — | — | WO | disclosed |
| EP-0763031-A1 | PIPERAZINE DERIVATIVES AS 5HT1A ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995033743-A1 | PIPERAZINE DERIVATIVES AS 5HT1A ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1995-12-14 | — | — | WO | disclosed |
| US-4585871-A | Process for oxidizing halopyridines to halopyridine-N-oxides | OLIN CORPORATION (US) | 1986-04-29 | — | — | US | disclosed |
| US-4504667-A | Process for oxidizing halopyridines to halopyridine-N-oxides | OLIN CORPORATION (US) | 1985-03-12 | — | — | US | disclosed |
| EP-0130333-A1 | Process for oxidizing halopyridines to halopyridine-N-oxides | OLIN CORPORATION (US) | 1985-01-09 | — | — | EP | disclosed |
| EP-0090177-A1 | Process for oxidizing halopyridines to halopyridine-N-oxides | OLIN CORPORATION (US) | 1983-10-05 | — | — | EP | disclosed |