Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1045012 | 0.79 | KDM4E (0.35) | GAAMEN1HCRTR1MAPTCASP1 | |
| SCHEMBL13784861 | 0.71 | GAA (0.39) | GAAMEN1HCRTR1MAPTCASP1 | |
| SCHEMBL17490721 | 0.70 | GAA (0.35) | GAAMEN1HCRTR1MAPTCASP1 | |
| SCHEMBL16707454 | 0.63 | GABRA1 (0.41) | ALDH1A1GABRA1GABRB2 | |
| SCHEMBL22637799 | 0.62 | MAPT (0.54) | GAAMEN1HCRTR1MAPTCASP1 | |
| SCHEMBL22637800 | 0.62 | MAPT (0.54) | GAAMEN1HCRTR1MAPTCASP1 | |
| SCHEMBL21597560 | 0.61 | SMN1; SMN2 (0.33) | MEN1KMT2A | |
| SCHEMBL16707452 | 0.61 | GABRA1 (0.39) | ALDH1A1GABRA1GABRB2 | |
| SCHEMBL77248 | 0.61 | — | — | |
| SCHEMBL22637380 | 0.61 | MAPT (0.38) | GAAMEN1HCRTR1MAPTCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6011053-A | USE TO ELEVATE HDL CHOLESTEROL CONCENTRATIONS, WHICH MAY BE USEFUL IN THE TREATMENT OF ATHEROSCLEROTIC CONDITIONS SUCH AS DYSLIPOPROTEINEMIAS AND CORONARY HEART DISEASE. | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-01-04 | — | — | US | disclosed |
| WO-1999011618-A1 | SUBSTITUTED INDOLE-1-CARBOTHIOIC ACID AMIDES AS NOVEL ANTIATHEROSCLEROTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-11 | — | — | WO | disclosed |
| US-4108982-A | DIURETICS, HYPOTENSIVE AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1978-08-22 | — | — | US | disclosed |