Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | PLA2G7 | Q13093 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8133116 | 0.87 | PLA2G7 (0.53) | MAPK1PLA2G7MEN1KMT2AMAOB | |
| SCHEMBL8138900 | 0.82 | SMN1; SMN2 (0.49) | PLA2G7TSHRTP53MEN1KMT2A | |
| SCHEMBL8134087 | 0.81 | PLA2G7 (0.51) | MAPK1PLA2G7MEN1KMT2AMAOB | |
| SCHEMBL4415602 | 0.80 | PLA2G7 (0.56) | MAPK1PLA2G7DAO | |
| SCHEMBL8141989 | 0.79 | PLA2G7 (0.48) | MAPK1PLA2G7TP53MEN1KMT2A | |
| SCHEMBL8133720 | 0.78 | PLA2G7 (0.52) | MAPK1PLA2G7MAOBSMN1; SMN2DAO | |
| SCHEMBL8139546 | 0.77 | MAOB (0.56) | PLA2G7TSHRTP53MEN1KMT2A | |
| SCHEMBL8132048 | 0.76 | PLA2G7 (0.60) | PLA2G7MAOBSMN1; SMN2DAOCTSB | |
| SCHEMBL8139821 | 0.75 | PLA2G7 (0.53) | PLA2G7TSHRMAOBSMN1; SMN2DAO | |
| SCHEMBL8135226 | 0.75 | PLA2G7 (0.63) | PLA2G7MAOBSMN1; SMN2DAOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028955-A1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SmithKline Beecham p.l.c. (GB) | 2000-08-23 | — | — | EP | claimed |
| WO-1999024420-A1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM PLC (GB) | 1999-05-20 | — | — | WO | claimed |