Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F12 | P00748 | 11/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30899467 | 0.76 | F12 (0.48) | F12F2 | |
| SCHEMBL30899466 | 0.76 | F12 (0.48) | F12F2 | |
| SCHEMBL1906311 | 0.76 | F12 (0.48) | F12F2 | |
| SCHEMBL7008464 | 0.75 | F12 (0.47) | F12PARP1KDM4ERECQLP2RX7 | |
| SCHEMBL18259028 | 0.75 | KDM1A (0.34) | GSK3B | |
| SCHEMBL31669380 | 0.75 | GSK3B (0.33) | P2RX7GSK3B | |
| Hydrochloric Acid SCHEMBL29279631 | 0.74 | F12 (0.47) | F12F2 | |
| Hydrochloric Acid SCHEMBL30899457 | 0.74 | F12 (0.47) | F12F2 | |
| SCHEMBL21920702 | 0.74 | FNTA (0.33) | GSK3B | |
| SCHEMBL34463425 | 0.73 | GSK3B (0.34) | KDM4EGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1007526-A1 | SUBSTITUTED 4-OXO-NAPTHYRIDINE-3-CARBOXAMIDES AS GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2000-06-14 | — | — | EP | claimed |
| WO-1999010347-A1 | SUBSTITUTED 4-OXO-NAPTHYRIDINE-3-CARBOXAMIDES AS GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1999-03-04 | — | — | WO | claimed |
| EP-1007526-A1 | SUBSTITUTED 4-OXO-NAPTHYRIDINE-3-CARBOXAMIDES AS GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2000-06-14 | — | — | EP | disclosed |
| WO-1999010347-A1 | SUBSTITUTED 4-OXO-NAPTHYRIDINE-3-CARBOXAMIDES AS GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1999-03-04 | — | — | WO | disclosed |