Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11909733 | 0.70 | HSD11B1 (0.31) | HSD11B1 | |
| SCHEMBL39976 | 0.67 | CYP2C9 (0.42) | HSD11B1EPHX1CYP2C9 | |
| SCHEMBL16593662 | 0.66 | — | — | |
| Lithium SCHEMBL5510213 | 0.65 | CYP2C9 (0.40) | HSD11B1EPHX1CYP2C9 | |
| SCHEMBL343777 | 0.65 | ATM (0.43) | — | |
| SCHEMBL7491232 | 0.65 | — | — | |
| SCHEMBL4910786 | 0.63 | EPHX1 (0.37) | HSD11B1EPHX1CYP2C9 | |
| SCHEMBL6862681 | 0.63 | HSD11B1 (0.35) | HSD11B1EPHX1CYP2C9 | |
| SCHEMBL1048761 | 0.63 | HSD11B1 (0.35) | HSD11B1EPHX1CYP2C9 | |
| SCHEMBL10584202 | 0.63 | CYP2C9 (0.38) | HSD11B1EPHX1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024110477-A2 | SYNTHESIS OF A CYCLIC PEPTIDE | JANSSEN PHARMACEUTICA NV (BE) | 2024-05-30 | — | — | WO | claimed |
| CN-111875607-A | Preparation method of chiral pyrrolopyrimidine compound | 正大天晴药业集团股份有限公司 | 2020-11-03 | — | — | CN | claimed |
| CN-108699063-B | Synthesis process of luccotinib | 正大天晴药业集团股份有限公司 | 2020-06-26 | — | — | CN | claimed |
| US-9908888-B2 | Processes for preparing pyrazolyl-substituted pyrrolo[2,3-d]pyrimidines | INCYTE CORPORATION (US) | 2018-03-06 | — | — | US | claimed |
| EP-2663309-B1 | PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES | INFINITY PHARMACEUTICALS INC (US) | 2017-03-15 | — | — | EP | claimed |
| CN-103648499-B | Processes for preparing isoquinolinones and solid forms of isoquinolinones | 无限药品股份有限公司 | 2017-02-15 | — | — | CN | claimed |
| US-20160152619-A1 | PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES | HCR COLLATERAL MANAGEMENT, LLC | 2016-06-02 | — | — | US | claimed |
| US-9290497-B2 | Processes for preparing isoquinolinones and solid forms of isoquinolinones | INFINITY PHARMACEUTICALS, INC. (US) | 2016-03-22 | — | — | US | claimed |
| US-20140371450-A1 | PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES | HCR COLLATERAL MANAGEMENT, LLC | 2014-12-18 | — | — | US | claimed |
| EP-2663309-A1 | PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES | Infinity Pharmaceuticals, Inc. (US) | 2013-11-20 | — | — | EP | claimed |
| WO-2012145932-A1 | A NOVEL PROCESS FOR THE PREPARATION OF PERAMIVIR AND INTERMEDIATES THEREOF | PHARMARESOURCES (SHANGHAI) CO., LTD. (CN) | 2012-11-01 | — | — | WO | claimed |
| US-20120184568-A1 | PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES | HCR COLLATERAL MANAGEMENT, LLC | 2012-07-19 | — | — | US | claimed |
| WO-2012097000-A1 | PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES | REN PINGDA (US) | 2012-07-19 | — | — | WO | claimed |
| US-5449778-A | Peptide intermediates | WARNER-LAMBERT COMPANY (US) | 1995-09-12 | — | — | US | claimed |
| EP-0637305-A1 | NOVEL CYCLIC AMINO ACIDS AND DERIVATIVES THEREOF | WARNER-LAMBERT COMPANY (US) | 1995-02-08 | — | — | EP | claimed |
| US-5264577-A | Cyclic amino acids and derivatives thereof | WARNER-LAMBERT COMPANY (US) | 1993-11-23 | — | — | US | claimed |
| WO-1993021176-A1 | NOVEL CYCLIC AMINO ACIDS AND DERIVATIVES THEREOF | WARNER-LAMBERT COMPANY (US) | 1993-10-28 | — | — | WO | claimed |
| US-20240218014-A1 | SYNTHESIS OF A CYCLIC PEPTIDE | JANSSEN PHARMACEUTICA NV (BE) | 2024-07-04 | — | — | US | disclosed |
| WO-1993021176-A1 | NOVEL CYCLIC AMINO ACIDS AND DERIVATIVES THEREOF | WARNER-LAMBERT COMPANY (US) | 1993-10-28 | — | — | WO | disclosed |
| WO-1992011284-A1 | TETRAPEPTIDE DERIVATIVES AND ANALOGUES | THE JAMES BLACK FOUNDATION LIMITED (GB) | 1992-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240218014-A1 | SYNTHESIS OF A CYCLIC PEPTIDE | VIP, QPCT, PTMS | HSD11B1 2178/4885EPHX1 3797/4885CYP2C9 2942/4885 |
| US-20160152619-A1 | PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES | PIK3CA, PIK3CD, PDPK1 | HSD11B1 1202/4885EPHX1 2852/4885CYP2C9 627/4885 |
| US-20120184568-A1 | PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES | PIK3CA, PDPK1, AKT3 | HSD11B1 1117/4885EPHX1 2842/4885CYP2C9 778/4885 |
| US-20140371450-A1 | PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES | PIK3CA, PDPK1, AKT3 | HSD11B1 1117/4885EPHX1 2842/4885CYP2C9 778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.