Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | DPYD | Q12882 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 14/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8156264 | 0.80 | JAK2 (0.52) | JAK2THRBDPYDALDH1A1 | |
| SCHEMBL22783664 | 0.72 | JAK2 (0.61) | JAK2THRBDHODHLMNAALDH1A1 | |
| SCHEMBL25391975 | 0.70 | JAK2 (0.59) | JAK2THRBDHODHLMNAALDH1A1 | |
| SCHEMBL10962665 | 0.70 | JAK2 (0.59) | JAK2THRBDHODHLMNAALDH1A1 | |
| SCHEMBL8148038 | 0.68 | JAK2 (0.57) | JAK2THRBDHODHLMNAALDH1A1 | |
| SCHEMBL11130450 | 0.68 | JAK2 (0.57) | JAK2THRBDHODHLMNAALDH1A1 | |
| SCHEMBL44527 | 0.68 | JAK2 (1.00) | JAK2THRBDHODHLMNAALDH1A1 | |
| SCHEMBL190140 | 0.68 | JAK2 (0.57) | JAK2THRBDHODHALDH1A1 | |
| SCHEMBL9715507 | 0.68 | JAK2 (1.00) | JAK2THRBDHODHLMNAALDH1A1 | |
| SCHEMBL122310 | 0.68 | JAK2 (0.57) | JAK2THRBDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445239-A4 | ANTI-MALARIAL COMPOSITION AND METHOD OF USE | — | 1992-03-25 | — | — | EP | claimed |
| EP-0445239-A1 | ANTI-MALARIAL COMPOSITION AND METHOD OF USE | THE CATHOLIC UNIVERSITY OF AMERICA (US) | 1991-09-11 | — | — | EP | claimed |
| WO-1991000081-A2 | ANTI-MALARIAL COMPOSITION AND METHOD OF USE | THE CATHOLIC UNIVERSITY OF AMERICA (US) | 1991-01-10 | — | — | WO | claimed |
| US-6159953-A | Anti-malarial composition and method of use | CATHOLIC UNIVERSITY OF AMERICA (US) | 2000-12-12 | — | — | US | disclosed |
| EP-0445239-A4 | ANTI-MALARIAL COMPOSITION AND METHOD OF USE | — | 1992-03-25 | — | — | EP | disclosed |
| EP-0445239-A1 | ANTI-MALARIAL COMPOSITION AND METHOD OF USE | THE CATHOLIC UNIVERSITY OF AMERICA (US) | 1991-09-11 | — | — | EP | disclosed |
| WO-1991000081-A2 | ANTI-MALARIAL COMPOSITION AND METHOD OF USE | THE CATHOLIC UNIVERSITY OF AMERICA (US) | 1991-01-10 | — | — | WO | disclosed |