Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 6/20 | 0.41 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | DPYD | Q12882 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8141792 | 0.80 | JAK2 (0.52) | JAK2THRBDPYDALDH1A1 | |
| SCHEMBL22783664 | 0.72 | JAK2 (0.61) | JAK2THRBKDM4EALDH1A1HPGD | |
| Water SCHEMBL147605 | 0.71 | JAK2 (0.96) | JAK2THRBALDH1A1 | |
| SCHEMBL25391975 | 0.70 | JAK2 (0.59) | JAK2THRBALDH1A1 | |
| SCHEMBL10962665 | 0.70 | JAK2 (0.59) | JAK2THRBKDM4EALDH1A1 | |
| SCHEMBL475086 | 0.68 | KDM4E (0.46) | IDO1ATMKDM4EDPYDGLA | |
| SCHEMBL6694829 | 0.68 | KDM4E (0.52) | JAK2IDO1ATMKDM4EDPYD | |
| SCHEMBL10371514 | 0.68 | TYMP (0.46) | IDO1ATMKDM4EDPYDGLA | |
| SCHEMBL11130450 | 0.68 | JAK2 (0.57) | JAK2THRBALDH1A1 | |
| SCHEMBL44527 | 0.68 | JAK2 (1.00) | JAK2THRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445239-A4 | ANTI-MALARIAL COMPOSITION AND METHOD OF USE | — | 1992-03-25 | — | — | EP | claimed |
| EP-0445239-A1 | ANTI-MALARIAL COMPOSITION AND METHOD OF USE | THE CATHOLIC UNIVERSITY OF AMERICA (US) | 1991-09-11 | — | — | EP | claimed |
| WO-1991000081-A2 | ANTI-MALARIAL COMPOSITION AND METHOD OF USE | THE CATHOLIC UNIVERSITY OF AMERICA (US) | 1991-01-10 | — | — | WO | claimed |
| US-6159953-A | Anti-malarial composition and method of use | CATHOLIC UNIVERSITY OF AMERICA (US) | 2000-12-12 | — | — | US | disclosed |
| EP-0445239-A4 | ANTI-MALARIAL COMPOSITION AND METHOD OF USE | — | 1992-03-25 | — | — | EP | disclosed |
| EP-0445239-A1 | ANTI-MALARIAL COMPOSITION AND METHOD OF USE | THE CATHOLIC UNIVERSITY OF AMERICA (US) | 1991-09-11 | — | — | EP | disclosed |
| WO-1991000081-A2 | ANTI-MALARIAL COMPOSITION AND METHOD OF USE | THE CATHOLIC UNIVERSITY OF AMERICA (US) | 1991-01-10 | — | — | WO | disclosed |