Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8142200 | 1.00 | AKR1B1 (0.53) | AKR1B1HRH1LMNATBXA2R | |
| SCHEMBL8137781 | 0.89 | AKR1B1 (0.54) | AKR1B1HRH1LMNATBXA2R | |
| SCHEMBL8137785 | 0.89 | AKR1B1 (0.54) | AKR1B1HRH1LMNATBXA2R | |
| SCHEMBL8614712 | 0.81 | HRH1 (0.50) | HRH1LMNA | |
| SCHEMBL8614715 | 0.81 | HRH1 (0.50) | HRH1LMNA | |
| SCHEMBL8143124 | 0.81 | TBXA2R (0.53) | TBXA2R | |
| SCHEMBL8143121 | 0.81 | TBXA2R (0.53) | TBXA2R | |
| SCHEMBL8126089 | 0.79 | AKR1B1 (0.43) | AKR1B1HRH1LMNA | |
| SCHEMBL8126092 | 0.79 | AKR1B1 (0.43) | AKR1B1HRH1LMNA | |
| SCHEMBL9045798 | 0.73 | TBXA2R (0.58) | TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549352-B1 | Tricyclic compounds as angiotensin II antagonists | KYOWA HAKKO KOGYO KK (JP) | 2000-03-01 | — | — | EP | disclosed |
| US-5478840-A | Imidazo(4,5-b)pyridine derivatives used as antagonism to angiotensin ii receptors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5378701-A | Angiotensin II inhibitors; hypotensive agents; congestive heart and kidney failure; glaucoma | KYOWA HAKKO KOGYO (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0549352-A2 | Tricyclic compounds as angiotensin II antagonists | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-06-30 | — | — | EP | disclosed |