Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.45 |
| ▸ | SRC | P12931 | 5/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 8/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 7/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.39 |
| ▸ | KDR | P35968 | 7/20 | 0.39 |
| ▸ | LYN | P07948 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 6/20 | 0.36 |
| ▸ | FLT4 | P35916 | 6/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CSK | P41240 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6640577 | 0.71 | FGFR1 (0.61) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL6641074 | 0.70 | SRC (0.50) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL8143371 | 0.70 | FGFR1 (0.67) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL8147144 | 0.66 | FGFR1 (0.56) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL4679454 | 0.63 | FGFR1 (0.46) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL6640144 | 0.62 | FGFR1 (0.65) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL6639851 | 0.61 | FGFR1 (0.53) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL6641921 | 0.60 | FGFR1 (0.69) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL16291626 | 0.60 | KDM5B (0.46) | CHRM2KMT2A | |
| SCHEMBL16293037 | 0.60 | CHRM2 (0.44) | CHRM2KDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003745-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY LLC (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009030-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-02-25 | — | — | WO | disclosed |