Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 19/20 | 0.67 |
| ▸ | SRC | P12931 | 13/20 | 0.67 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8150824 | 0.82 | SRC (0.70) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL8142094 | 0.78 | FGFR1 (0.55) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL6639245 | 0.72 | FGFR1 (0.53) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL8143441 | 0.70 | FGFR1 (0.45) | FGFR1SRCFGFR2FGFR4FGFR3 | |
| SCHEMBL10276720 | 0.68 | FGFR1 (0.65) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL6643606 | 0.66 | FGFR1 (1.00) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL8130561 | 0.64 | FGFR1 (0.89) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL5619944 | 0.64 | SRC (0.56) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL29536840 | 0.64 | FGFR1 (0.45) | FGFR1SRCEGFRFGFR2FGFR4 | |
| SCHEMBL5659394 | 0.64 | FGFR1 (0.45) | FGFR1SRCEGFRFGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003745-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY LLC (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009030-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-02-25 | — | — | WO | disclosed |