Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | QPCT | Q16769 | 8/20 | 0.42 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8143992 | 1.00 | NAMPT (0.43) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7753776 | 0.85 | TBXA2R (0.42) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7753772 | 0.85 | TBXA2R (0.42) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8135713 | 0.81 | NAMPT (0.40) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8135718 | 0.81 | NAMPT (0.40) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8134103 | 0.79 | QPCT (0.47) | NAMPTQPCTABCC9KCNJ11 | |
| SCHEMBL8134099 | 0.79 | QPCT (0.47) | NAMPTQPCTABCC9KCNJ11 | |
| SCHEMBL8137254 | 0.78 | KCNJ11 (0.48) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8143957 | 0.78 | KCNJ11 (0.51) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8137250 | 0.78 | KCNJ11 (0.48) | NAMPTCYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147098-A | USEFUL IN THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM, PULMONARY SYSTEM, GASTROINTESTINAL SYSTEM AND ENDOCRINOLOGIC SYSTEM | NOVO NORDISK A/S (DK) | 2000-11-14 | — | — | US | disclosed |