Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.53 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.53 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.53 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.53 |
| ▸ | FAP | Q12884 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23173625 | 0.94 | CACNA2D1 (0.47) | CACNA2D1CACNA1BCACNB1CACNA1CFAP | |
| SCHEMBL23173789 | 0.87 | CACNA2D1 (0.41) | CACNA2D1CACNA1BCACNB1CACNA1CFAP | |
| SCHEMBL24307350 | 0.86 | CACNA2D1 (0.51) | CACNA2D1CACNA1BCACNB1CACNA1CBDKRB1 | |
| SCHEMBL25571572 | 0.85 | CACNA2D1 (0.55) | CACNA2D1CACNA1BCACNB1CACNA1CBDKRB1 | |
| SCHEMBL1308937 | 0.82 | MEN1 (0.54) | CACNA2D1CACNA1BCACNB1CACNA1CBDKRB1 | |
| SCHEMBL8230809 | 0.81 | TDP1 (0.50) | FAPDPP4PREPNPSR1L3MBTL1 | |
| SCHEMBL8138867 | 0.81 | CACNA2D1 (0.44) | CACNA2D1CACNA1BCACNB1CACNA1CNPSR1 | |
| SCHEMBL23174010 | 0.81 | CACNA2D1 (0.45) | CACNA2D1CACNA1BCACNB1CACNA1CBDKRB1 | |
| SCHEMBL4067141 | 0.80 | CYP1A2 (0.55) | CACNA2D1CACNA1BCACNB1CACNA1CBDKRB1 | |
| SCHEMBL26705105 | 0.79 | CACNA2D1 (0.49) | CACNA2D1CACNA1BCACNB1CACNA1CBDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119741-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2008-10-09 | — | — | WO | disclosed |