Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.39 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8146081 | 0.88 | CRHR1 (0.37) | CRHR1BRD9BRD7 | |
| SCHEMBL8145397 | 0.81 | CRHR1 (0.39) | CRHR1PDE10A | |
| SCHEMBL8145070 | 0.80 | — | — | |
| SCHEMBL8128658 | 0.78 | CRHR1 (0.41) | CRHR1BRD9BRD7PDE10A | |
| SCHEMBL8148157 | 0.76 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL8148200 | 0.76 | TSHR (0.38) | CRHR1 | |
| SCHEMBL8152915 | 0.73 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL7031036 | 0.73 | — | — | |
| SCHEMBL7030091 | 0.72 | — | — | |
| SCHEMBL8145796 | 0.68 | CRHR1 (0.33) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994877-A1 | IMIDAZOPYRIMIDINES AND IMIDAZOPYRIDINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | Du Pont Pharmaceuticals Company (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999001454-A1 | IMIDAZOPYRIMIDINES AND IMIDAZOPYRIDINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-01-14 | — | — | WO | disclosed |