SCHEMBL8145304

SCHEMBL8145304

Nc1ccc(F)c(Oc2ccc(C(F)(F)F)c(Oc3c(F)ccc(N)c3C(F)(F)F)c2)c1C(F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
AR P10275 8/20 0.43
ALOX5AP P20292 1/20 0.36
FEN1 P39748 1/20 0.36
HTR2A P28223 1/20 0.36
SLC6A4 P31645 1/20 0.36
KCNH2 Q12809 1/20 0.36
SCN9A Q15858 2/20 0.33
CDK8 P49336 1/20 0.33
MAPT P10636 2/20 0.33
KIF11 P52732 1/20 0.33
POLB P06746 1/20 0.33
HSP90AA1 P07900 1/20 0.33
NR4A1 P22736 1/20 0.33
L3MBTL1 Q9Y468 2/20 0.32
NPSR1 Q6W5P4 1/20 0.32
RAB9A P51151 1/20 0.31
THRA P10827 1/20 0.31
THRB P10828 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8153457 0.90 AR (0.37) ARALOX5APFEN1MAPTNR4A1
SCHEMBL8147207 0.87 AR (0.41) ARALOX5APFEN1HTR2ASLC6A4
SCHEMBL8144471 0.85 AR (0.37) ARALOX5APFEN1HTR2ASLC6A4
SCHEMBL8146200 0.83 AR (0.40) ARALOX5APFEN1HTR2ASLC6A4
SCHEMBL8147212 0.83 AR (0.34) ARMAPTKIF11HSP90AA1L3MBTL1
SCHEMBL8146007 0.83 AR (0.32) ARMAPTPOLBHSP90AA1L3MBTL1
SCHEMBL8137329 0.83 AR (0.36) ARALOX5APFEN1MAPTNR4A1
SCHEMBL8138446 0.82 AR (0.37) ARALOX5APFEN1HTR2ASLC6A4
SCHEMBL8146989 0.81 ALOX5AP (0.38) ARALOX5APFEN1HTR2ASLC6A4
SCHEMBL8138749 0.80 AR (0.32) ARL3MBTL1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed